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Impatient readers may choose to skip directly to Section 6 for the conclusion and tips on practical application. 

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Impatient readers may choose to skip directly to Section 6 for the conclusion and tips on practical application. 


Abbreviation list


MEFmurine embryonic fibroblasts
HUVECshuman umbilical vein endothelial cells
SCAPssenescent cell antiapoptotic pathways
SASPsenescence-associated secretory phenotype
BWbodyweight
IMR90human embryonic lung fibroblasts
SA-β-galsenescence-associated beta-galactosidase
p16Ink4aa tumor suppressor protein
p21Cip1cell-cycle regulatory protein that Interacts with cyclin-CDK2 and -CDK4, inhibiting cell cycle progression at G1
MCP-1monocyte chemotactic protein-1

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